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1) N,2-fluorenylacetamide:
a. causes bladder cancer in male and female Slonaker rats.
b. causes liver cancer in male Wistar rats and breast cancer in female Wistar rats.
c. causes intestinal cancer in male and female Piebald rats.
2) N-nitrosodiethylamine:
a. causes liver tumours in Norway (BD II) rats, white-tailed rats, chickens, guinea pigs, NMRI mice and Syrian golden hamsters at doses for each species that varied a thousandfold.
3) Ethyl carbamate:
a. causes high incidences of cancer in certain mouse strains but not in the X/Gf mouse strain.
4) Dimethyl-benzo-alpha-anthracene:
a. causes lymphomas in Swiss mice
b. causes bronchial adenomas in the Strong A mouse strain
c. causes hepatomas (liver cancer) in male mice of other strains
5) Benzidine:
a. causes bladder cancer in humans
b. causes tumours of the acoustic nerve, intestine & liver in mice
6) Carbontetrachloride (CC1):
a. causes liver tumours in mice
b. produces cirrhosis of the liver in rats
7) Chloroform (CHC1) (see above)
a. produces liver tumours in various strains of female mice but not in male mice
8) DDT:
a. causes liver tumours in mice but not in rats or hamsters.
9) Sodium saccharin (artificial sweetener):
a. causes bladder cancer only in male rats
b. does not affect monkeys, hamsters or mice, even at high doses.
c. shows no evidence of bladder cancer in human population studies.
10) Arsenic:
a. is carcinogenic in humans
b. is not carcinogenic in rodents
11) Benzidine and 2-naphthylamine:
a. causes bladder cancer in humans and dogs
b. causes liver and mammary tumours in rats
c. causes mostly liver tumours in mice and hamsters
12) Glass fibre products:
a. Experiments on rats, guinea pigs, rabbits and monkeys in the 1950s produced no lung damage when the animals were forced to inhale glass fibres. A later analysis in the 1980s revealed that hamsters, guinea pigs, mice and monkeys exposed to glass fibres, glass wool or mineral wool did not produce lung tumours following long-term inhalation.
b. In 1991, the US Occupational Health and Safety Administration decided that glass fibre products should be labelled as a potential cancer hazard because, contrary to the results of animal experiments, studies in industry workers showed an increased risk of lung cancer.
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